We are dedicated to a better understanding of metabolic disorders and to developing mechanism-driven therapeutic and preventive rationales for human metabolic diseases such as diabetes, obesity, and cancer.
The epidemics of metabolic diseases is growing rapidly and, along with the associated cancer risk, it has led to significantly increased healthcare cost (shown in the diagram). As the primary metabolic platform, mitochondria show various defects in individuals with diabetes, obesity, and cancer. We seek to understand the molecular mechanism of mitochondrial alterations and metabolic disorders, with the goal to develop mechanism-based therapeutic and preventive rationales for human metabolic diseases. Our top priority is set to scholarship and professional development in the lab, where people can enjoy not only science and discovery but also scholarship and stewardship. All members are expected to work individually, collaboratively, and sportively so everyone can be productive and well prepared for the future career.
Previous studies have suggested genetic and environmental factors, as well as gene-environment interactions (epigenetics), are significantly associated with metabolic disorders. How genetic, epigenetic and environmental factors regulate mitochondrial function is the topic of intensive research in our lab. The ongoing projects include:
We employ interdisciplinary techniques and foster a broad collaboration with the research laboratories of chemistry, biochemistry, molecular and cellular biology, genetics, and bioinformatics.
Longhua has received his PhD degree and is starting a postdoctoral training at Columbia University. Congratulations and enjoy New York, Dr. Liu (Longhua)!